A ready-to-drink low phenylalanine* (Phe) medical food for use in the dietary management of Phenylketonuria (PKU). 

Now with lower Phe: 30 mg per carton.

PKU sphere liquid carton is suitable from 3 years of age.


View full product information (carton)

For more resources about living with PKU and low-protein diets, visit VitafriendsPKU now.

Request Sample


  • Contains glycomacropeptide (GMP) from a natural whole protein source: offering a different taste to amino acid based medical foods which may be preferred by some individuals with PKU1-4
  • 20 g protein equivalent (PE) in ONLY one 8 fl oz carton to help achieve daily intake of PE in the lowest volume**
  • Convenient and resealable carton: easy to take on-the-go to daycare, school, work, or when traveling 
  • Wide range of vitamins, minerals and DHA to support adequate intake of nutrients lacking in the typical PKU diet5-9 
  • Can be taken as is or easily customized with permitted flavorings

* Each 8 fl oz carton contains 30 mg of phe

** Among ready-to-drink GMP-based medical foods for PKU.





1. Lim K, et al. Acceptable low-phenylalanine foods and beverages can be made with glycomacropeptide from cheeses whey for individuals with PKU. Mol Gen Metab. 2007; 31:92(1):176–8.

2. Van Calcar SC, et al. Improved nutritional management of Phenylketonuria by using a diet containing glycomacropeptide compared with amino-acids. Am J Clin Nutr. 2009; 89(4):1068–77.

3. Ney, D. Glycomacropeptide for nutritional management of phenylketonuria: a randomized, controlled, crossover trial. Am J Clin Nutr. 2016; 104(2):334–45.

4. Proserpio C, et al. Exploring Drivers of Liking of Low-Phenylalanine Products in Subjects with Phenylketonuria Using Check-All-That-Apply Method. Nutrients. 2018; 10(9):1179.

5. Couce ML, et al. Effects of LC-PUFA Supplementation in Patients with Phenylketonuria: A Systematic Review of Controlled Trials. Nutrients. 2019; 11(7):1537.

6. Reilly C, et al. Trace element nutrition status and dietary intake of children with phenylketonuria. Am J Clin Nutr. 1990; 52(1):159–165.

7. Barretto JR, et al. Poor zinc and selenium status in phenylketonuric children and adolescents in Brazil. Nutr Res. 2008; 28(3):208–211.

8. Gokmen-Ozel HA, et al. Long-term efficacy of ‘ready-to-drink’ protein substitute in phenylketonuria. J Hum Nutr Diet. 2009; 22(5):422–427.

9. Knerr I, Blessing H. Seyferth S, Watling RJ, and Chaudhri MA. Evaluation of plasma trace element and mineral status in children and adolescents with phenylketonuria using data from inductively-coupled-plasma atomic emission and mass spectrometric analysis. Ann Nutr Metab. 2013; 63(1-2):168–173.

Nutrition Information

per 237 ml (1 carton)

  • 120  


  • 20 g

    Protein Equivalent

  • 6.6 g 


  • 1.2 g

    Total Fat

  • 109 mg


Ordering & Reimbursement Information



Product Number

Reimbursement Code


PKU sphere liquid 


15 x 8 fl oz

(15 x 237 ml)




B4162 & B4157