PKU sphere®

+The PKU sphere formula comparison is based on other PKU formulas participants have used in the past and/or were currently taking at the time of the survey.
*Based on 2022 third party online survey results from 27 individuals ages 13 years and above with PKU in North America. Survey reflects flavors available at the time: Red Berry, Chocolate, and Vanilla.

1. Rackerby et al. Food Sci Anim Resour, 2024.
2. Sawin et al. Am J Physiol GI, 2015 .
3. Daly A et al., J Hum Nutr Diet, 2017.
4. Daly A et al., Orphanet J Rare Dis, 2019
5. Couce ML, et al. Effects of LC-PUFA Supplementation in Patients with Phenylketonuria: A Systematic Review of Controlled Trials. Nutrients. 2019; 11(7):1537.
6. Reilly C, et al. Trace element nutrition status and dietary intake of children with phenylketonuria. Am J Clin Nutr. 1990; 52(1):159–165.
7. Barretto JR, et al. Poor zinc and selenium status in phenylketonuric children and adolescents in Brazil. Nutr Res. 2008; 28(3):208–211.
8. Gokmen-Ozel HA, et al. Long-term efficacy of ‘ready-to-drink’ protein substitute in phenylketonuria. J Hum Nutr Diet. 2009; 22(5):422–427.
9. Knerr I, Blessing H. Seyferth S, Watling RJ, and Chaudhri MA. Evaluation of plasma trace element and mineral status in children and adolescents with phenylketonuria using data from inductively-coupled-plasma atomic emission and mass spectrometric analysis. Ann Nutr Metab. 2013; 63(1-2):168–173.